Extracellular matrix hydrogels from decellularized tissues: structure and function

Saldin, Lindsey T.; Cramer, Madeline C; Velankar, Sachin S; White, Lisa J.; Badylak, Stephen F.

doi:10.1016/j.actbio.2016.11.068

Extracellular matrix hydrogels from decellularized tissues: structure and function

Saldin, Lindsey T.; Cramer, Madeline C; Velankar, Sachin S; White, Lisa J.; Badylak, Stephen F.

Authors

Lindsey T. Saldin

Madeline C Cramer

Sachin S Velankar

Dr LISA WHITE LISA.WHITE@NOTTINGHAM.AC.UK
Associate Professor

Stephen F. Badylak

Abstract

Extracellular matrix (ECM) bioscaffolds prepared from decellularized tissues have been used to facilitate constructive and functional tissue remodeling in a variety of clinical applications. The discovery that these ECM materials could be solubilized and subsequently manipulated to form hydrogels expanded their potential in vitro and in vivo utility; i.e. as culture substrates comparable to collagen or Matrigel, and as injectable materials that fill irregularly-shaped defects. The mechanisms by which ECM hydrogels direct cell behavior and influence remodeling outcomes are only partially understood, but likely include structural and biological signals retained from the native source tissue. The present review describes the utility, formation, and physical and biological characterization of ECM hydrogels. Two examples of clinical application are presented to demonstrate in vivo utility of ECM hydrogels in different organ systems. Finally, new research directions and clinical translation of ECM hydrogels are discussed

Citation

Saldin, L. T., Cramer, M. C., Velankar, S. S., White, L. J., & Badylak, S. F. (2017). Extracellular matrix hydrogels from decellularized tissues: structure and function. Acta Biomaterialia, 49, https://doi.org/10.1016/j.actbio.2016.11.068

Journal Article Type	Article
Acceptance Date	Nov 30, 2016
Online Publication Date	Dec 1, 2016
Publication Date	Feb 1, 2017
Deposit Date	Sep 15, 2017
Publicly Available Date	Sep 15, 2017
Journal	Acta Biomaterialia
Print ISSN	1742-7061
Electronic ISSN	1878-7568
Publisher	Elsevier
Peer Reviewed	Peer Reviewed
Volume	49
DOI	https://doi.org/10.1016/j.actbio.2016.11.068
Keywords	Extracellular matrix; Hydrogel; Decellularization; Naturally derived; Injectable; Regenerative medicine; Biomaterial; Tissue engineering
Public URL	https://nottingham-repository.worktribe.com/output/837520
Publisher URL	http://www.sciencedirect.com/science/article/pii/S174270611630664X?via%3Dihub
Contract Date	Sep 15, 2017

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0